Irrational Games have released the minimum PC specs that players will have to meet in order to play the game on their favorite platform. The details were confirmed earlier today, here are stats. 
 
In terrific news, Irrational Games also confirmed that the game will have full key-mapping, allowing gamers to “remap all the default action bindings, with both primary and alternate bindings available simultaneously” according to a post on the Irrrational website.
 
The company also made it a point to state the game will not apply “artificial mouse smoothing”, and you can “control sensitivity or toggle mouse acceleration in the options screen”.
 
If you prefer a controller, that will be an option as well. There will be “separate controller layouts (Default, Marksman, and Retro), each of which support loads of configuration options”. Bioshock Infinite will also allow (aim assist, sensitivity, vibration, and look inversion and left-handedness).
 
All UI’s in the game are controllable via either keyboard and mouse or the console controller, and you can switch back and forth between the two input paradigms without ever pausing the game.
 
As for UI and graphic settings there are other fine details to mention. New “horizontal plus” widescreen support will be added to the game, “the wider you go, the more you’ll see of Columbia’s gorgeous vistas. And for the true aficionado, we support multi-monitor gaming with AMD Eyefinity, NVIDIA Surround, and Matrox TripleHead2Go” is also available states Irrational Games. Players will also have separate controls for aspect ratio, resolution, and display mode (fullscreen, windowed, and fullscreen windowed).
 
Here are some interesting graphic options:

We have six different graphics presets, from “Very Low” to “Ultra,” providing a wide range of quality-versus-performance options. Gamers who want to tweak those further can switch to a Custom configuration, which gives you control over anti-aliasing, texture detail, texture filtering, dynamic shadows, post-processing, light shafts, ambient occlusion, and object level of detail. Many of these options have setting levels that are only available under DX11.
 
That’s right—BioShock Infinite is a DX11 game. Though you only need DX10-compatible hardware to play, having a DX11 graphics card gives you access to contact-hardening dynamic shadows, diffusion depth of field, high definition ambient occlusion and optimized antialiasing. Each of these features was developed in close collaboration with AMD’s graphics experts to take maximum advantage of modern DX11 hardware.
 
Finally, to show off all of that glorious PC pixel-pushing power, we’re shipping with unadulterated, full-resolution textures right in the box. You may not enjoy the three-DVD install, but we hope you will appreciate the jaw-dropping detail our amazing team of artists lavished on the game.

The game wil also support STEAM cloud saves and STEAM Big Picture support.
 
MINIMUM

• OS: Windows Vista Service Pack 2 32-bit
• Processor: Intel Core 2 DUO 2.4 GHz / AMD Athlon X2 2.7 GHz
• Memory: 2 GB
• Hard Drive: 20 GB free
• Video Card: DirectX10 Compatible ATI Radeon HD 3870 / NVIDIA 8800 GT / Intel HD 3000 Integrated Graphics
• Video Card Memory: 512 MB
• Sound Card: DirectX Compatible

RECOMMENDED

• OS: Windows 7 Service Pack 1 64-bit
• Processor: Quad Core Processor
• Memory: 4 GB
• Hard Drive: 30 GB free
• Video Card: DirectX11 Compatible, AMD Radeon HD 6950 / NVIDIA GeForce GTX 560
• Video Card Memory: 1024 MB
• Sound Card: DirectX Compatible

source: irrational